Detalhe da pesquisa
1.
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ß2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett
; 41: 127975, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33753262
2.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35901125
3.
Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance.
Int J Pharm
; 606: 120893, 2021 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34274456
4.
Inter-compound and Intra-compound Global Sensitivity Analysis of a Physiological Model for Pulmonary Absorption of Inhaled Compounds.
AAPS J
; 22(5): 116, 2020 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32862303
5.
Building in-house PBPK modelling tools for oral drug administration from literature information.
ADMET DMPK
; 7(1): 4-21, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-35350741
6.
Dissecting the Pharmacodynamics and Pharmacokinetics of MSCs to Overcome Limitations in Their Clinical Translation.
Mol Ther Methods Clin Dev
; 14: 1-15, 2019 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31236426
7.
Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension.
Eur J Pharmacol
; 850: 126-134, 2019 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30753868
8.
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.
PLoS One
; 6(1): e16406, 2011 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-21307957
9.
Development and validation of a high-throughput method for the quantitative analysis of D-amphetamine in rat blood using liquid chromatography/MS3 on a hybrid triple quadrupole-linear ion trap mass spectrometer and its application to a pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci
; 878(1): 21-8, 2010 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19945359
10.
In vivo rat PK profiling in drug discovery: new challenges.
Expert Opin Drug Discov
; 5(11): 1031-7, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22827743